Ladder only runewords, by default, are not able to be used in Single Player in Diablo II: Lord of Destruction.
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Here is a tutorial on how to make this happen without using PlugY.
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I advise to close out of any Diablo II client completely before doing this.
1) Download this file: https://drive.google.com/file/d/1beQ_i4y7eBMftTOzsPrFVX5ZrXFWL9Jw/view?usp=sharing
2.) Place the Rune.txt file in your Diablo II Folder under «Diablo IIdataglobalexcel» Please note, these folders may need to be created!
EDIT: 11/5/2016 — *If you are still having issues with this, sometimes removing the .txt from Runes.txt fixes it because it hides known file types. It would look like Runes.txt.txt with file types shown
3.) Right click on your Diablo 2 shortcut → properties → Add «-direct -txt» in the target line after «…Diablo IIDiablo II.exe»
4.) Test runewords!
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This is being tested on a Windows 7 64bit computer, it should also work fine on Windows 10 as well. Latest patch 1.14D.
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Having an issue getting Diablo 2 to work? Check out this video!
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Special Thanks and credit goes to this thread for making this possible: http://www.gamefaqs.com/boards/370600-diablo-ii-lord-of-destruction/62650884
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****MAC RESPONSE***
Copied from previous response of John Hammer: It will work on a Mac but you will need to use the Terminal to launch the game rather than double-clicking in the Finder or clicking on the alias in the Dock. Find the Diablo II application icon in the Finder (it should be inside a folder called Diablo II). It is not actually an application but a «package». Right-click on the Diablo II application package and choose SHOW PACKAGE CONTENTS. You will then see a folder called CONTENTS, click on that and you will see nested folders one of which is called MacOS; click on MacOS. In there you will see the actual Diablo II executable application. Now open a Terminal window. Drag the Diablo II executable application to the Terminal prompt. Doing so will put in the correct path to the application so you don’t have to try to type it yourself. You can then add any arguments after that, such as -direct -txt or perhaps -act5 (which starts new single-player characters at Level 33) or ALMOST anything else that works on Windows. Remember that you also need that text file placed in the proper location in order to get this Ladder-Only Runewords fix to work. You can use an Automator Script if you want to launch the game this way frequently (pretty much the same as a Windows shortcut) but it’s better to do it only when you want to create ladder-only runewords.
Updated January 15th, 2018
*Updated new link to rune.txt file, previous link broke.
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